Public Pathways Collection

Neonatal Pathways & Guidelines

A curated collection of publicly available clinical pathways and guidelines from leading academic neonatal institutions across the US, organized by clinical system.

● Respiratory

Apnea of Prematurity

Respiratory
Children’s Minnesota Guideline University of North Carolina Guideline UC Davis Guideline

BPD

Respiratory
UC Davis Guideline

BPD Discharge

Respiratory
University of North Carolina Guideline

BPD PAH Screening

Respiratory
Children's Hospital of Philadelphia Pathway UC Davis Guideline

BPD Post-NICU

Respiratory
Children's Hospital of Philadelphia Pathway

Difficult Airway/Airway Emergency

Respiratory
Children's Hospital of Philadelphia Pathway Children’s Mercy Guideline University of North Carolina Guideline

HFJV

Respiratory
Johns Hopkins Pathway University of North Carolina Guideline UC Davis Guideline

Invasive Ventilation

Respiratory
Johns Hopkins Pathway University of North Carolina Guideline

Invasive Ventilation, 28-30wk

Respiratory
University of North Carolina Guideline

Lower Resp Infection

Respiratory
Children's Hospital Orange County Guideline Dell Children's Guideline

Non-invasive Ventilation

Respiratory
Johns Hopkins Guideline

Non-invasive Ventilation, Bubble CPAP

Respiratory
Dell Children's Pathway University of North Carolina Guideline

Non-invasive Ventilation, Post-Extubation

Respiratory
Johns Hopkins Pathway

Oxygen Saturations

Respiratory Development
Johns Hopkins Pathway

Oxygen Weaning Outpatient

Respiratory Discharge Planning
Children' Hospital Colorado Pathway

Passy-Muir Valve Initiation

Respiratory ENT
Children's Minnesota Guideline

Persistent Pulmonary Hypertension, Nitric Oxide (PPHN/iNO)

Respiratory Cardiac
Children's Hospital of Philadelphia Pathway Nationwide Children's Pathway University of North Carolina Guideline

Post-natal Steroids

Respiratory
Johns Hopkins Pathway University of North Carolina Guideline UC Davis Guideline

Premedication for Intubation

Respiratory
University of North Carolina Guideline UC Davis Guideline

Pulmonary Hemorrhage

Respiratory
Children's Hospital of Philadelphia Pathway

Surfactant, LISA

Respiratory
UC Davis Guideline

Tracheoplasty

Respiratory Surgery
Stanford Pathway

Tracheostomy

Respiratory ENT Surgery
University of North Carolina Pathway

Tracheostomy, BPD

Respiratory ENT Surgery
University of North Carolina Guideline

Tracheostomy, Post-Op Guideline

Respiratory ENT Surgery
Children's Hospital Orange County Guideline

iNO

Respiratory Cardiac
University of North Carolina Guideline

● Cardiac

CVICU Infant Feeding Guideline

Cardiac
Children’s Hospital Orange County Guideline Johns Hopkins Pathway Children's Hospital of Philadelphia Pathway

CVICU Post-Op Chest Tube

Cardiac
Stanford Pathway

Cardioversion/Defibrillation/Pacing

Cardiac
UC Davis Guideline

Coarctation of the Aorta

Cardiac
Arch Watch, Johns Hopkins Pathway Arch Watch, Stanford Pathway

Fontan (Post-Op)

Cardiac
Children’s Hospital Orange County Guideline Children's Nebraska Pathway

Heart Failure (Acute)

Cardiac
Children's Hospital of Philadelphia Pathway

Hypotension

Cardiac
Iowa Guideline University of North Carolina Guideline

Junctional Ectopic Tachycardia (CVICU)

Cardiac
Children's Hospital Orange County Guideline Children's Nebraska Pathway Johns Hopkins Pathway

Norwood

Cardiac
Stanford Pathway

Patent Ductus Arteriosus (PDA)

Cardiac Premature / <1500g
Children's Hospital of Philadelphia Pathway Johns Hopkins Pathway Iowa Guideline UC Davis Guideline

Pericardial Effusion (Post-Op)

Cardiac
Children's Mercy Guideline

Pulmonary Atresia, Intact Ventricular Septum

Cardiac
Johns Hopkins Pathway

Single Ventricle Tube Feeding/Weaning

Cardiac Nutrition Discharge Planning
Children's Nebraska Pathway

Tetralogy of Fallot Repair

Cardiac
Children's Hospital Orange County Guideline Stanford Pathway

Transposition of the Great Arteries

Cardiac
Children's Hospital of Philadelphia Pathway

● Neurology

BRUE

Neurology
Children’s Hospital Orange County Guideline Children's Hospital of Philadelphia Pathway Children’s Mercy Guideline Children’s Minnesota Guideline Dell Children’s Guideline Johns Hopkins Pathway Nationwide Children’s ED Pathway Nationwide Children’s IP Pathway Texas Children’s Guideline

Brachial Plexus

Neurology
Children’s Hospital Orange County Guideline

Hypoxic Ischemic Encephalopathy/Therapeutic Hypothermia

Neurology
Children’s Hospital of Atlanta Guideline Children's Hospital of Philadelphia Pathway Johns Hopkins Pathway Nationwide Children's Pathway University of North Carolina Guideline UC Davis Pathway

NOWS

Neurology
Children's Hospital of Philadelphia Pathway University of North Carolina Guideline

NOWS, Human Milk

Neurology
Johns Hopkins Pathway

Neuroprotection

Neurology
Johns Hopkins Pathway

Pain

Neurology
Children's Hospital Orange County Guideline Children's Hospital of Philadelphia Pathway Johns Hopkins Pathway University of North Carolina Guideline

Pain, CVICU Extubated

Neurology
Children's Hospital Orange County Guideline

Pain, CVICU Intubated

Neurology
Children's Hospital Orange County Guideline

Posthemorrhagic Hydrocephalus

Neurology Surgery Development
Children's Hospital of Philadelphia Pathway University of North Carolina Guideline

Seizures

Neurology
Children’s Hospital of Atlanta Pathway Children’s Hospital Colorado Pathway Children’s Hospital Orange County Guideline Children's Hospital of Philadelphia Pathway Children's Nebraska Pathway Stanford Pathway University of North Carolina Guideline UC Davis Guideline

Seizures, >1mon of age

Neurology
Children's Minnesota Guideline

Seizures, Status Epilepticus >1mon of age

Neurology
Children’s Hospital Orange County Guideline Johns Hopkins Pathway

Seizures, Status Epilepticus >28d

Neurology
Nationwide Children's Pathway

Tethered Cord

Neurology Surgery
Children's Hospital of Philadelphia Pathway Johns Hopkins Pathway UC Davis Guideline

cEEG Guideline

Neurology
Children's Hospital Orange County Guideline Children's Hospital of Philadelphia Pathway Dell Children's Guideline

● Surgery

Antibiotic Prophylaxis for Surgery

Surgery
Children’s Hospital Orange Country Guideline Children’s Minnesota Guideline University of North Carolina Guideline

Bilious Emesis

Surgery
UC Davis Resource

CDH

Surgery
Children’s Hospital Orange County Guideline Children's Hospital of Philadelphia Pathway Children’s Mercy Pathway University of North Carolina Guideline UC Davis Guideline

CDH, Postnatal

Surgery
Dell Children’s Pathway

CDH, Prenatal

Surgery
Dell Children’s Guideline

Chylothorax (Post-Op)

Surgery
Children’s Hospital Orange County Guideline Children’s Nebraska Pathway Johns Hopkins Pathway UC Davis Guideline

Cleft Lip/Palate

Surgery
Children's Hospital Colorado Pathway Children’s Hospital Orange County Guideline Johns Hopkins Pathway

Enterostomy Management

Surgery Nutrition
UC Davis Guideline

GJ Tube Conversion

Surgery
UC Davis Guideline

GTube

Surgery
Children's Hospital of Philadelphia Pathway Nationwide Children's Pathway University of North Carolina Guideline UC Davis Guideline

Gastroschisis

Surgery
Arkansas Children's Pathway Children’s Hospital Orange County Guideline Johns Hopkins Pathway University of North Carolina Guideline UC Davis Pathway

Hirschsprung’s Disease

Surgery
Children's Hospital Orange County Guideline

Intestinal Atresia

Surgery
Children's Hospital Orange County Guideline

Micrognathia/Mandibular Distraction

Surgery
Children's Hospital Orange County Guideline Children's Hospital of Philadelphia Pathway Children's Mercy Guideline

Necrotizing Enterocolitis (NEC)

Surgery
Arkansas Children's Pathway Children's Hospital Orange County Guideline Johns Hopkins Pathway University of North Carolina Guideline

Neural Tube Defect

Surgery
Children's Hospital of Philadelphia Pathway Children's Mercy Guideline University of North Carolina Guideline UC Davis Guideline

Omphalocele

Surgery
Children's Hospital Orange County Guideline

Periop/NPO

Surgery
Children's Hospital of Philadelphia Pathway Children's Minnesota Guideline

Post-Sedation Monitoring

Surgery
Children's Minnesota Pathway

Pyloric Stenosis

Surgery
Children's Hospital Orange County Guideline Children's Minnesota Guideline Johns Hopkins Pathway Nationwide Children's Pathway

Short Bowel/Intestinal Failure

Surgery Nutrition
Children's Hospital Orange County Guideline UC Davis Guideline

Spontaneous Intestinal Perforation (SIP)

Surgery
Children's Hospital Orange County Guideline

TEF/EA

Surgery
Children's Hospital Orange County Guideline University of North Carolina Guideline UC Davis Guideline

● GI / Gastroenterology

Biliary Atresia

GI / Gastroenterology
Dell Children’s Guideline

Cow’s Milk Protein Allergy

GI / Gastroenterology
Children’s Hospital Orange County Guideline

GERD

GI / Gastroenterology
Johns Hopkins Pathway UC Davis Guideline

● Infectious Disease

Congenital CMV

Infectious Disease
Children’s Minnesota Guideline Children's Hospital Colorado Pathway

Congenital CMV (Asymptomatic)

Infectious Disease
Johns Hopkins Pathway

Conjunctivitis

Infectious Disease
Children’s Mercy Guideline

Early Onset Sepsis (EOS)

Infectious Disease
Children’s Hospital Orange County Guideline Johns Hopkins Pathway UC Davis Guideline

HSV

Infectious Disease
Children’s Hospital Orange County Guideline Johns Hopkins Pathway Iowa Guideline

Late Onset Sepsis

Infectious Disease
Children's Hospital Orange County Guideline Children's Hospital of Philadelphia Pathway Johns Hopkins Pathway Iowa Guideline University of North Carolina Guideline UC Davis Guideline

Staph Screening/Decolonizing

Infectious Disease
Johns Hopkins Pathway University of North Carolina Guideline UC Davis Guideline

● Nutrition

BPD Nutrition

Nutrition
Johns Hopkins Pathway

Discharge Feeding

Nutrition
Johns Hopkins Pathway University of North Carolina Guideline

Feeding Guideline

Nutrition
Johns Hopkins Pathway Stanford Pathway University of North Carolina Guideline UC Davis Guideline

Lipids

Nutrition
Johns Hopkins Pathway

Metabolic Bone Disease/Vit D

Nutrition
Johns Hopkins Pathway Nationwide Children's Pathway

Oral Feeding

Nutrition Discharge Planning Development
Johns Hopkins Guideline Nationwide Children's Pathway UC Davis Pathway

Parenteral Nutrition

Nutrition
Johns Hopkins Pathway University of North Carolina Guideline UC Davis Guideline

Vitamins/Supplements

Nutrition
Johns Hopkins Pathway

● Endocrine

Adrenal Insufficiency

Endocrine
UC Davis Guideline

Hyperglycemia

Endocrine
University of North Carolina Guideline UC Davis Guideline

Hypoglycemia

Endocrine
Children's Hospital of Philadelphia Pathway Johns Hopkins Pathway

Stress Dose/Perioperative Steroids

Endocrine Surgery
Children's Hospital of Philadelphia Pathway Children's Mercy Guideline Stanford Pathway University of North Carolina Guideline

Thyroid Screening

Endocrine
Children's Hospital of Philadelphia Pathway

● Hematology

Exchange Transfusion

Hematology
Children's Hospital of Philadelphia Pathway Children's Hospital of Philadelphia Pathway University of North Carolina Guideline

Hyperbilirubinemia

Hematology
University of North Carolina Guideline University of North Carolina Guideline

Transfusion

Hematology
Dell Children's Guideline Johns Hopkins Pathway University of North Carolina Guideline

● Vascular Access

IV Access

Vascular Access
Dell Children's Pathway Stanford Pathway UC Davis Guideline

Lymphatic Disorders

Vascular Access
Children's Hospital of Philadelphia Pathway

● Discharge Planning

Home NG

Discharge Planning Nutrition
Johns Hopkins Pathway UC Davis Guideline

● Development

Skin-to-Skin Care

Development
Johns Hopkins Pathway

● Obstetrics

Congenital Heart Disease Deliveries

Obstetrics
Johns Hopkins Pathway

High Risk Delivery

Obstetrics
Nationwide Children's Pathway

Periviability

Obstetrics Resuscitation
Johns Hopkins Pathway University of North Carolina Guideline UC Davis Guideline

● Resuscitation

Post-Arrest Care

Resuscitation
Children's Hospital of Philadelphia Pathway Dell Children's Pathway Stanford Pathway

● Palliative Care

DNR

Palliative Care
University of North Carolina Guideline

Palliative Care

Palliative Care
University of North Carolina Guideline UC Davis Guideline

● ECMO

ECMO, Airway Bleed

ECMO
Children's Nebraska Pathway

ECMO, Echos

ECMO
Children's Nebraska Pathway

ECMO, Neuromonitoring

ECMO
Children's Mercy Pathway

● Renal

Acute Kidney Injury/Failure

Renal
University of North Carolina Guideline Children’s Hospital Colorado Pathway

● ENT

Ankyloglossia

ENT
Children's Hospital of Philadelphia Pathway

● GU / Urology

Disorders of Sexual Differentiation

GU / Urology Endocrine
Children's Mercy Guideline

Hypospadias

GU / Urology
Dell Children's Pathway

Undescended Testicle

GU / Urology
Children's Hospital of Colorado Pathway

● Dermatology

Atopic Dermatitis

Dermatology
Children's Hospital of Philadelphia Pathway

Epidermolysis Bullosa

Dermatology
Children's Hospital Orange County Guideline

Hemangioma

Dermatology
Children’s Hospital Orange County Guideline

● Genetics

22q11.2 Deletion Screening

Genetics
Children's Hospital of Philadelphia Pathway

Hyperammonemia

Genetics
Children's Hospital Colorado Pathway Children's Hospital of Philadelphia Pathway Nationwide Children's Pathway

Trisomy 21 Swallowing

Genetics Nutrition Discharge Planning
Children's Hospital of Colorado Pathway

Beckwith-Wiedemann

Genetics
Children's Hospital of Philadelphia Pathway

Mitochondrial Disease

Genetics
Children's Hospital of Philadelphia Pathway

● Mother-Baby Unit

Cyanotic Events on Well Baby

Mother-Baby Unit
Stanford Pathway

● Plastics / Craniofacial

Craniosynostosis

Plastics / Craniofacial
Stanford Pathway

● Premature / <1500g

ELBW

Premature / &lt;1500g
University of North Carolina Guideline UC Davis Guideline

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● Consensus Statements

Institutional and national consensus statements synthesizing current evidence for neonatal practice

CHOP Division of Neonatology — Consensus Statements

US

Children's Hospital of Philadelphia — clinical consensus statements on key neonatal topics. Click a topic to go directly to that statement.

Transfusion Oxygen Targeting Parenteral Nutrition Late Preterm Care Ventilation View all →

AAP Committee on Fetus & Newborn (COFN)

US

American Academy of Pediatrics — authoritative COFN policy statements and clinical reports. Click a topic to go directly to that guideline.

Hyperbilirubinemia Apnea of Prematurity NICU Discharge Human Milk / VLBW Levels of Care View all →

● Regulatory & Professional Organization Guidelines

Guidelines from international regulatory bodies and professional organizations governing neonatal practice standards

ILCOR — Neonatal Life Support (2025 CoSTR)

International

International Liaison Committee on Resuscitation — globally accepted 2025 Consensus on Science with Treatment Recommendations for neonatal resuscitation.

NLS CoSTR Evidence Reviews 2025 NLS CoSTR (Circulation) All ILCOR Publications →

NRP 9th Edition — AHA/AAP Neonatal Resuscitation Guidelines (2025)

US

American Academy of Pediatrics & American Heart Association — 2025 NRP 9th Edition based on the updated ILCOR CoSTR, now the standard of care for neonatal resuscitation.

NRP Program Overview 2025 AHA/AAP Guidelines Part 5: Neonatal Resus (Circulation) What's New in NRP 9th Ed →

ELSO — ECMO Guidelines

International

Extracorporeal Life Support Organization — comprehensive evidence-based guidelines for ECMO and extracorporeal life support. Click a topic to go directly to that guideline.

All ELSO Guidelines Neonatal Respiratory Failure ECMO Transport

British Association of Perinatal Medicine (BAPM)

International

BAPM — freely available evidence-based Frameworks for Practice. Click a topic to go directly to that framework.

Extreme Preterm Hypothermia Difficult Airway Family Integrated Care Bilious Vomiting View all →

NICE — Neonatal & Infant Guidelines

International

National Institute for Health and Care Excellence — freely accessible evidence-based guidelines. Click a topic to go directly to that guideline.

Neonatal Infection Preterm Respiratory Jaundice Preterm Labour Parenteral Nutrition View all →

Know of a public pathway resource?

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